Chronic blood loss is one of the more common clinical conditions. Generally speaking, according to the different causes of blood loss, the treatment method is also different. First, if the patient’s gastroscopic examination reveals that the chronic blood loss is caused by chronic gastritis or gastric ulcer, he can take pantoprazole, Daxi tablets, colloidal bismuth pectin to protect the gastric mucosa and reduce the ulcer wound, so as to completely cure the chronic blood loss. Second, if gastroscopy found that the chronic blood loss is caused by gastric malignant tumor, it is necessary to assess the physical condition of the patient, the patient can tolerate surgery can be performed radical treatment of gastric cancer, complete removal of the tumor and bleeding, trauma to achieve the purpose of hemostasis. For patients who cannot tolerate surgery, endoscopic spraying of hemostatic drugs can be given to play the role of palliative care. For chronic ulcerative colitis and chronic blood loss caused by colon polyps found in colonoscopy, endoscopic polypectomy or herbal enema can be given to treat chronic intestinal inflammation, which can achieve the effect of hemostasis.