Causes of oropharyngeal cancer include chemical carcinogens, physical carcinogens and biological carcinogens. Oropharyngeal cancer is most common in male patients aged 50~70 years old, and the causes of the disease are many, including chemical carcinogens, physical carcinogens and biocarcinogens. Chemical carcinogens are mainly benzo(a)pyrene contained in tobacco, in addition, alcohol can be used as a solvent for carcinogens, which also has carcinogenic risk to a certain extent. Physical carcinogenic factors are mainly unsuitable dentures, sharp dental crests, stumps, etc. in the oral cavity, which can cause long-term inflammation by continuous friction with the buccal mucosa and lingual side sources, which is then called carcinogenic factors. Biological carcinogenic factors such as human papilloma virus (HPV) can also enter the human oral cavity through sexual behavior and lead to oropharyngeal cancer, and long-term poor oral hygiene is also a factor contributing to oropharyngeal cancer in patients. In addition, factors such as susceptibility, malnutrition, heredity, race, radiation and so on are also associated with the occurrence of oropharyngeal cancer to a certain extent. Patients who have doubts about the causes of oropharyngeal cancer can go to otorhinolaryngology, head and neck surgery or oncology department of regular hospitals for further consultation.