Melasma on both sides of the cheeks can be removed by topical medication, systemic medication, physical therapy and other measures. 1. Topical medication: Commonly used medications include decolorizers, which can inhibit tyrosinase activity and reduce pigment production, such as hydroquinone cream, azelaic acid cream and compound arbutin cream; retinoic acid can also be used, which can affect melanin metabolism and has certain curative effect on chloasma. 2. Systemic medication: Vitamin C, vitamin E and tranexamic acid can be taken orally, and vitamin C can be injected intravenously in large doses in serious cases. 3. Physical therapy: Q-switched large spot low-energy laser and intense pulsed light have certain effect on melasma. If you have chloasma on both sides of your cheeks, you need to go to the hospital for checkup first, follow the doctor’s prescription for medication, and avoid abusing medication by yourself.