Quadruple drugs are mostly H. pylori eradication drugs, and bleeding in the stool after taking quadruple drugs is considered to be related to bismuth, but it is mostly black stool. Bleeding or fresh blood in the stool is more likely to consider hemorrhoids. The quadruple medication includes proton pump inhibitors, antibiotics, and bismuth. Since it includes antibiotics, patients may experience nausea, vomiting, abdominal pain, diarrhea, and other gastrointestinal disorders after taking it. The quadruple dose also includes bismuth, which may cause symptoms of dark stools after taking the medication. If you find bleeding in the stool, you first need to figure out if it is blood, because ingesting pigments in food can also affect the color of the stool, commonly by consuming red dragon fruit. If it is indeed fresh blood in the stool, hemorrhoids are most often considered, sometimes accompanied by perianal discomfort and so on. Bismuth and food factors caused by most of the stopping the drug and change the diet after the stool to return to normal, if continued bloody stools, it is recommended to immediately go to the local regular hospital gastroenterology or anorectal examination, to rule out gastrointestinal bleeding and hemorrhoids, do not delay, so as not to delay the condition.