Liver failure may be caused by viruses, drugs, tumors, etc. 1. Viruses: Common liver viruses that cause liver failure include hepatitis A, B, C, D and E, as well as some rare viruses such as cytomegalovirus, EBV, herpesvirus and yellow fever virus. Hepatitis causes cell necrosis and leads to severe liver damage and failure. 2. Drugs: acetaminophen, isoniazid, methyldopa, tetracycline and antiepileptic drugs. Most of these drugs are metabolized by the liver, which can directly damage liver cells and lead to different degrees of liver cell necrosis. 3. Liver tumors: for example, hepatocellular carcinoma. Cancer cells directly destroy liver cells, leading to severe liver dysfunction and liver failure. Liver failure can also be seen in other causes, it is recommended to consult a doctor in time, follow the doctor’s instructions to carry out relevant examinations, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.