The main solutions for hand sweating are giving antiperspirants, botulinum toxin type A, oral anticholinergic medications, and surgery. Hyperhidrosis is the excessive sweating of the hands. The cause of hand sweating is not clear, but it is considered to be related to heredity and over-activation of cholinergic sympathetic nerves. It is necessary to first go to the hospital skin consultation, to determine the cause of hand sweating, can be combined with the doctor’s advice to give antiperspirants, such as aluminum chloride hexahydrate, aluminum chloride tetrachloride, can make the hand sweating significantly reduced. Botulinum toxin type A, which blocks the release of acetylcholine from cholinergic neurons, can also be given. By intradermal injection, sweat production can be effectively reduced. If necessary, oral anticholinergic drugs can be given in conjunction with a doctor’s advice, and the commonly used clinical treatments include Gronbutam and Oxybutynin. If the above treatments are not effective, there is another treatment method, which is selective sympathectomy done by thoracic surgery. There are more treatments for hand sweating to avoid the side effects of long-term medication and excessive dosage of medication. So, the treatment needs to be done under the supervision of a doctor.