The possible causes of peeling and cracking of the toe seam are fungal infection, eczema, etc., which can be improved by medication and enhanced care. 1. Fungal infection: the most common cause of cracked toes is fungal infection of the foot, i.e. tinea pedis, in which impregnated erosion type is often manifested as impregnated whitish skin of the toes, the surface of the skin is soft and easy to peel off, revealing reddish vesicles and oozing, often accompanied by fissures and itching and other symptoms. Such patients can use boric acid solution, esacridine and other drugs for wet compresses, astringent wounds, to reduce the exudation of the toe seam and then local application of ketoconazole, miconazole, terbinafine hydrochloride and other drugs to help antifungal treatment, which effectively improves the symptoms of peeling cracked toe seam. 2. Eczema: Frequent wearing of poorly ventilated shoes and socks, sweat impregnation, and minor skin injuries caused by athletic friction may lead to the occurrence of chronic eczema of the feet, with symptoms such as peeling and cracking. Such patients can be applied locally with compound flumethasone ointment, tacrolimus ointment and other drugs to help anti-inflammatory, anti-allergy treatment; combined with obvious itching symptoms can be oral loratadine, cetirizine hydrochloride tablets and other antihistamines to help treatment. It should be noted that the above drugs need to be used under the guidance of a physician to avoid the occurrence of adverse reactions; patients should pay attention to strengthen the care during the treatment period, to keep the feet clean, and thus help better treatment.