Creatinine 150μmol/L does not necessarily develop into uremia, whether it will develop into uremia is related to the cause of elevated creatinine and whether it is effectively treated. If acute kidney injury is actively treated, creatinine can be normalized in some patients, while chronic kidney injury is generally difficult to recover and may develop into renal failure. In addition, those caused by physiological factors will not develop into uremia. Normal creatinine value is 53~106μmol/L for male and 44~97μmol/L for female, and creatinine 150μmol/L is on the high side. Creatinine is mainly filtered by kidney and then discharged with urine, thus the value of creatinine can reflect the condition of kidneys to a certain extent. If it is caused by acute renal impairment, usually after timely treatment of blood replenishment, fluid replenishment and relief of urinary tract obstruction factors, some patients’ condition will be recovered and will not develop into uremia. If the creatinine is elevated due to chronic kidney disease, it is difficult to recover even with timely treatment, and the disease can progress gradually and eventually develop into uremia. In addition, physiological factors such as excessive consumption of meat can also lead to elevated creatinine value, after adjusting the diet can generally return to normal, at this time will not develop into uremia. If creatinine is elevated, it is recommended to go to the hospital for relevant examinations to determine the cause of the disease and then follow the doctor’s instructions for the next step.