In general, after stopping isotretinoin, most people with mild symptoms of liver damage can have their liver recover gradually and their symptoms will gradually ease, but if the symptoms are more severe, the recovery time may be slower. Isotretinoin can treat acne by shrinking sebaceous gland tissues, inhibiting sebaceous gland activity, reducing sebum secretion, reducing epithelial cell keratinization, keratin embolism at the follicular sebaceous gland orifices, and inhibiting the growth and reproduction of Propionibacterium acnes, but it may have an effect on the liver. After prolonged use of isotretinoin, it may aggravate the burden on the liver. For patients with relatively mild symptoms of liver function impairment, liver function will also gradually return to normal after discontinuing the drug, but if the symptoms of liver function impairment are more serious, the recovery is slower, and it may also result in severe liver failure, which usually does not lead to a full recovery effect. No drug can be used for a long time, so as not to affect the metabolism of the liver and kidneys, aggravate the burden on the liver and kidneys, which is not conducive to good health. Usually, after stopping isotretinoin drugs, you need to go to the hospital regularly to do liver function and other related checks, but also through the method of blood sampling to test liver function, mainly to understand whether there is an abnormal lesion of liver function, and timely treatment of liver preservation, in order to avoid worsening of the symptoms of impaired liver function. In addition, it is also necessary to develop good habits, including work and rest habits, so as not to adversely affect the liver.