Itchy ears, a symptom, is often caused by different diseases, such as cerumen embolism, external ear eczema, fungal disease of the external auditory canal, etc., which need to be treated with targeted medication according to the condition, and there is no such thing as the most effective medication for this symptom. 1. Cerumen impaction: For patients with itchy ears caused by cerumen impaction, 5% sodium bicarbonate solution or liquid paraffin can be used to soften the cerumen and then remove it, or saline can be used to flush the ear canal for treatment. Patients with ear canal inflammation can be treated with antibiotics such as amoxicillin and levofloxacin as prescribed by the doctor. 2. Eczema of the outer ear: for patients with itchy ears caused by eczema of the outer ear, you can use topical medications under the guidance of a doctor, such as methyl viologen solution, prednisone ointment, mometasone furoate cream and other treatments, and you can also take antihistamines, such as chlortetracycline, cetirizine, etc. to alleviate the condition. For secondary infection patients, antibiotics can be used, such as erythromycin, amoxicillin and so on. 3. External auditory canal fungal disease: external auditory canal fungal disease caused by itchy ears, saline or 3% hydrogen peroxide can be used to clean the fungal clumps and scabs, swabbed dry with a dry cotton swab, and then locally coated with Dakinin cream, ketoconazole and so on. It is recommended that patients strictly follow the doctor’s instructions to use medication, do not change the dose of drugs or abuse drugs, pay attention to ear care in life, if any discomfort in a timely manner to seek medical attention.