Patients with HFMD may have fever and rash, which usually appears on the palmar side of the hands and feet, between the fingers, and in the mouth and buttocks, and in some cases on the thighs, knees, and elbows. The rash is usually a maculopapular, papular or herpetic rash, which can be surrounded by an inflammatory redness with little fluid, and can be accompanied by a sore throat and cough. Individual cases can develop into severe and critical cases with neurological involvement and cardiopulmonary insufficiency, such as poor mental health, irritability, drowsiness, easy startle, weakness of shaking limbs, as well as tachycardia, pallor, cold sweats, and chills at the end of the extremities. Individual patients will show signs of cardiopulmonary failure, shock and coma within 1-5 days. Therefore, early recognition of severe and critical cases is extremely important, along with proper treatment.