It is impossible to say whether it is important to have a high serum globulin or not. Depending on the type, the severity of the disease indicated by the high level varies, and there is also a relationship with the type of disease. Serum globulin is categorized into four types of serum globulin: α1, α2, β, and R. 1. 1. α1 globulin: When inflammation occurs in the liver, α1 globulin increases, and at this time, it indicates a milder disease. 2. α2 globulin: it can reflect the severity of hepatitis lesions. In the early stage of hepatitis, most of them remain normal, and with the development of the disease, the value increases gradually. 3. β-globulin: in cholestatic liver disease, most of them will increase. 4. r-globulin: increases in almost all hepatobiliary diseases, and unexplained persistent elevation often indicates deterioration of the disease. Individuals react differently to high serum globulin and it is recommended to improve the examination and standardize the treatment.