LDL is a risk factor for cardiovascular and cerebrovascular diseases. Whether LDL 3.8 mmol/L requires medication depends on whether the patient has other underlying diseases. 1. Combined with hypertension, diabetes and other underlying diseases. In this case, medication such as Rosuvastatin and other lipid-lowering drugs are needed to restore LDL to normal. To restore LDL to the normal range and lower the patient’s blood lipids, thus reducing the risk of cardio-cerebral diseases. 2. There is no combination of other underlying diseases. Clinically, some patients have high LDL due to long-term intake of high-fat, high-calorie food, triggering obesity, which can be caused by this kind of patients can first improve their lifestyle, strengthen physical exercise, lose weight to reduce blood lipids, and usually achieve the therapeutic purpose. Regardless of the situation, patients need to follow the doctor’s instructions, go to the hospital regularly for medical checkups, monitoring blood lipids and other data, so as not to delay the condition.