Elevated bilirubin is the release of bilirubin from the body into the bloodstream, resulting in increased concentration. It can be seen in liver damage and biliary obstruction caused by various reasons, etc. Whether it is serious or not depends on the cause of the disease as well as the liver function, pathogenetic tests, and imaging tests. Elevated bilirubin can be seen in various causes of liver damage, biliary obstruction, hematologic diseases such as hemolytic jaundice due to various causes and congenital hyperbilirubinemia, etc. Whether it is serious or not should be evaluated according to the cause of the disease as well as the comprehensive evaluation of liver function, pathogenetic tests, and imaging tests. Pathological elevation needs to be treated according to the etiology, such as immune disease leading to hemolysis, can be treated with glucocorticoids, can be effectively controlled. If the elevation is caused by biliary obstruction, interventional or surgical treatment is feasible to relieve the obstruction. Hepatocellular carcinoma can also lead to elevated bilirubin, which can be cured by early detection and surgical treatment, but the effect of late-stage treatment is not satisfactory. It is recommended to go to the hospital to check the cause of the disease and follow the doctor’s instructions to avoid delaying the disease.