Sildenafil can promote penile erection in the presence of sexual stimulation and is used for the treatment of penile erectile dysfunction and should be used under medical supervision.
Sildenafil is a cyclic guanosine monophosphate specific phosphodiesterase inhibitor class of drugs, when sexual stimulation leads to the release of local nitric oxide, it can inhibit the decomposition of cyclic guanosine monophosphate, so that its content in the corpus cavernosum is elevated, relaxing the smooth muscle, promoting blood inflow, and facilitating the erection of the penis. It is clinically used to treat penile erectile dysfunction, but requires sexual stimulation to work.
Sildenafil is prohibited for concomitant use with nitrate drugs such as isosorbide nitrate, guanylate cyclase agonists such as lioresiguanide, which may cause symptomatic hypotension, and is also contraindicated in people with a history of hypersensitivity to the components of this drug. Use this drug with caution in people with cardiovascular disease, as sexual intercourse carries a potential risk of cardiovascular events and requires a cardiologist to assess the suitability of the cardiac condition for sexual intercourse.
Sildenafil can cause adverse reactions such as headache, flushing, dyspepsia, abnormal vision, back pain and myalgia during use. It should be used under the supervision of a physician and immediate medical attention should be sought if discomfort occurs.