Irbesartan hydrochlorothiazide and amlodipine can usually be taken at the same time. 1. Irbesartan Hydrochlorothiazide: belongs to the compound preparation, after taking it, it can reduce the extracellular volume, lower peripheral vascular resistance, as well as inhibit the release of aldosterone, which is mainly used in the treatment of primary hypertension and other diseases. The drug may cause tachycardia, flushing, diarrhea and other discomforts after taking it. The drug is contraindicated in people who are allergic to the components of the drug and in people with severe renal impairment. Kidney function and blood pressure need to be monitored during the course of taking the drug, while pregnant and lactating women need to use the drug under the guidance of a doctor. 2. Amlodipine: belongs to the calcium channel blocker, after taking the drug can reduce the extracellular calcium ions into the vascular smooth muscle cells, reduce the contraction response of resistance vessels, mainly used in the treatment of essential hypertension, angina pectoris and other diseases. The drug may cause palpitations, nausea, edema, fatigue and other discomforts after taking it. It is contraindicated in people who are allergic to the components of the drug, in people with severe hypotension. Liver function and blood pressure need to be monitored in the process of taking the drug, and also need to follow the doctor’s instructions to take the drug, children and elderly patients need to use the drug under the guidance of the doctor. 3. Amlodipine and Irbesartan hydrochlorothiazide are antihypertensive drugs. If taking Irbesartan hydrochlorothiazide is ineffective in lowering blood pressure, it can be combined with amlodipine for antihypertensive treatment. The specific combination of treatment options is recommended to be decided by the doctor after a comprehensive assessment of the condition.