Whether blisters on the bottom of the feet can be picked after excessive exercise needs to be analyzed on a case-by-case basis. Most of the blisters on the soles of the feet are caused by excessive and prolonged exercise, excessive friction of the skin on the bottom of the feet, local skin damage and tissue fluid exudation. After the specifics of the blisters are clarified, a scientific and effective treatment plan can be used. 1, can not be picked: Although blisters appear on the bottom of the feet after excessive exercise, but the natural barrier role of the skin still exists, can wait for its own absorption, no need to pick. At this time, you need to stop strenuous exercise, sleep with your feet elevated to promote venous reflux. You can also disinfect the blister locally with iodophor and treat it with a topical aerosol spray of red medicine or antibiotic ointment, and wear loose, soft shoes and socks. The tension within the blister will gradually decrease and the fluid will absorb itself, after which the epidermis will fall off naturally; 2. Can be picked: those with previous foot odor, corns, with infection, suspected internal bleeding, etc. need to pick the blister, release the fluid, and find the ruptured blood vessels. Treatment can be applied to peroxide to wash off the pus, saline to rinse the wound, and iodophor disinfection, sterile gauze dressing, regular drug changes and other treatments. Take care not to eat spicy, cold and stimulating food during the medication change.