The main side effects of zonisamide are loss of appetite, drowsiness, and fatigue. Zonisamide is mainly used for grand mal seizures, limited seizures, petit mal seizures, and status epilepticus. Side effects of zonisamide include drowsiness, generalized weakness, loss of appetite, etc. Some patients may experience dyskinesia, elevated aminotransferases, lowered white blood cells, and diplopia and other reactions in a few patients. It is necessary to pay attention to the use of the drug, continuous use of the drug can not be suddenly stop or reduce the dose, need to regularly review the patient’s liver and kidney function, lactating women should be used with caution. This product can cause a decrease in attention and reflex motor ability, so drivers, operators of machinery should be used with caution. It is recommended that patients should follow the doctor’s instructions to avoid aggravation of the condition.