Involuntary twitching of the corners of the mouth in the elderly may be related to emotional excitement, or it may be caused by facial muscle spasm, Parkinson’s disease and other reasons. 1. Emotional excitement: when the elderly encounter certain stressful events stimulation, resulting in emotional over-excitement, resulting in increased sympathetic excitability, it may show the corner of the mouth involuntary twitching symptoms, without special intervention. 2. Facial muscle spasm: this disease may be caused by mechanical stimulation, facial nerve compression or poor recovery from facial nerve paralysis, etc. In the early stage of the disease, it mainly manifests as eyelid fluttering and gradually expands to the corners of the mouth as well as the entire facial muscles, which may cause involuntary twitching of the corners of the mouth, especially in the case of mental overstress, overfatigue and other situations, the symptoms will be aggravated significantly. 3. Parkinson’s disease: the disease belongs to the elderly neurodegenerative diseases, the patient’s typical symptoms for the static tremor, may show the corner of the mouth involuntary twitching, can also be accompanied by limb stiffness, unsteady gait and other manifestations. Involuntary twitching of the corners of the mouth in the elderly, may also be related to other factors, should seek medical attention as soon as possible, to clarify the cause of the disease, in the doctor’s guidance for treatment.