The best way to administer epinephrine is by intramuscular injection, which allows the patient to control the dose of the drug and to manage the dose according to the patient’s response, such as heart rate, blood pressure, pulse rate, and oxygen saturation. The intramuscular injection of epinephrine minimizes side effects such as arrhythmia or transient increase in blood pressure. Therefore, intramuscular injection is the best recommended method of adrenaline administration. In addition, epinephrine can also be administered by subcutaneous injection, but the application of subcutaneous injection must be diluted before administration, and the indications should be strictly controlled and the patient’s vital signs should be monitored for a long time.