The movie The Lover at the End of Time tells the story of Adaline, a young girl who miraculously doesn’t age and looks forever due to an accident. In the movie, the heroine played by Blake Lively traveled through the years, and was a male god harvester in every era, and was beautiful for 90 years. Art comes from life, and in real life, it is undoubtedly every woman’s dream to have an ageless face. When the wrinkles climbed on the corners of the eyes, the skin is no longer delicate, the years always in the woman’s face left a mark that is difficult to erase. With the progress of modern medicine, a variety of “anti-aging” therapies have emerged, and among the many facial rejuvenation methods, stem cell therapy is undoubtedly the “time machine” given by God. In addition to facial tissue laxity and displacement, facial aging is characterized by a decrease in skin quality and shrinkage of subcutaneous soft tissue volume. Autologous fat grafting is generally the first option for replenishing soft tissue volume. This is because autologous fat grafting has no rejection and the texture of the fat is soft and long lasting after survival. However, autologous fat grafting faces the problem of uncertain fat survival rate, and if there is a method that can improve the survival rate of fat grafting, then the problem that constrains fat grafting will be solved. There are many reports on cell-assisted fat grafting technology. Yoshimura et al. in Japan added stromal vascular components rich in fat-derived stem cells extracted from fat aspirates to granulated adipose tissue awaiting grafting, which increased the content of fat-derived stem cells in the grafted fat and enabled better fat grafting to achieve stable post-treatment results. As seen above, patients suffering from facial fat atrophy have significant facial filler results, good recovery and high fat retention after cell-assisted fat grafting. The transplantation of granular fat assisted by stem cells of fat origin can improve the survival rate of the transplanted fat and obtain stable post-treatment results, and this surgical operation is known as the cell-assisted fat transplantation technique, which has been reported and used both domestically and internationally. Meanwhile, a large number of experiments have shown that good post-treatment results have been achieved by adding fat-derived stem cells to granular fat for facial transplantation. And in the course of previous studies, it has been found that the transplanted areas of these patients receiving the treatment showed phenomena such as discoloration fading and skin texture becoming delicate, and some patients even repeatedly visited the clinic for fat stem cell facial transplantation treatment in order to pursue this improvement in skin texture. So, can adipose-derived stem cells be used in facial rejuvenation treatment? Scientists have launched a related study in which they mixed fat with stromal vascular components enriched with adipose-derived stem cells or adipose-derived mesenchymal stem cells for fat injection, and the results showed that facial rejuvenation could be achieved. The picture on the left is before treatment, the middle picture is the result after the combination of fat and stromal vascular component enriched with adipose-derived stem cells, and the right picture is the result of the combination of fat and mesenchymal adipose-derived mesenchymal stem cells. The dark staining in the figure is collagen fiber tissue. It can be seen that the latter two methods can significantly increase the amount of collagenous adventitial tissue in the skin, thus achieving facial rejuvenation. In addition, it has been demonstrated that adipose-derived stem cells can promote the healing of radiotherapy-induced wounds after breast cancer treatment. Adipose stem cells extracted from diabetic rats mixed with type I collagen matrix can promote the healing of diabetes-induced ulcer wounds. In a murine model of UV-induced wrinkles, dermal thickness and collagen content were increased after local injection of adipose-derived stem cells. Patients with nasal skin defects healed well without significant scarring or deformation after local injection of adipose-derived stem cells. Adipose-derived stem cells extracted from subcutaneous adipose tissue of burn patients can be cultured in vitro to produce vascularized skin tissue. These studies demonstrated side by side that adipose-derived stem cells can differentiate into epithelial cells or dermal fibroblasts in vivo, indirectly proving that adipose stem cells are involved in the repair and regeneration of skin tissues. Therefore, for the treatment of wrinkles, in addition to the filling effect of fat grafting itself, adipose-derived stem cells can also play a better role in promoting the repair and regeneration of skin tissues, i.e., rejuvenation of the therapeutic purpose, which can be said to be multi-purpose, and can be called God’s time machine for women.