When neuropathic toothache is more painful when it is hot or cold, anti-inflammatory drugs and painkillers should be taken orally to relieve the symptoms, such as metronidazole, cephalosporin and ibuprofen. However, the most effective method is root canal treatment. When neuropathic toothache is more painful when exposed to heat or cold, it is in line with the symptoms of irreducible pulpitis and acute phase of pulpitis, which will be relieved by taking anti-inflammatory drugs and painkillers, such as metronidazole, cephalosporin and ibuprofen. In irreducible pulpitis, the main symptom is that there is or was spontaneous pain, cold stimulation hurts, heat stimulation causes severe pain, and the pain persists longer after the stimulation is removed. The main focus is on root canal treatment, and anti-inflammatory medications are taken to relieve symptoms when they cannot be seen, such as metronidazole and cephalosporin. In the acute stage of endodontitis, the main symptom is sharp, severe pain, temperature stimulation will cause severe pain, the pain worsens at night, the pain can not be localized, there is radiating pain, timely root canal treatment is most effective. Metronidazole and cephalosporin can also be effective when taken without consultation and during treatment. Medications should be taken as prescribed, and are contraindicated for those who are allergic to metronidazole, cephalosporin, ibuprofen and other drugs.