Clopidogrel tablets can not be taken with anticoagulants, proton pump inhibitors, dihydropyridine calcium channel blockers, non-steroidal anti-inflammatory drugs, etc., as follows: 1. can not be used with anticoagulants, clopidogrel belongs to the inhibition of platelet aggregation, can be used to treat acute cerebral ischemic disease, anticoagulants such as warfarin, heparin, rivaroxaban, etc. and clopidogrel used in combination, will lead to an increased risk of bleeding. 2.. Proton pump inhibitors such as omeprazole, lansoprazole, etc. are used for peptic ulcer, reflux esophagitis, etc., will compete with clopidogrel for the same enzyme when metabolized by the liver, and the combination leads to a decrease in the inhibition of platelet aggregation of clopidogrel, a decrease in the therapeutic efficacy, and an increase in the risk of thrombosis, so the combination should be avoided. 3. The combination of clopidogrel tablets and dihydropyridine calcium channel blockers, such as amlodipine, nifedipine, felodipine, etc., may lead to a decrease in the antiplatelet effect and an increase in the risk of thrombosis, so the combination should be avoided. 4. Clopidogrel and non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen, celecoxib, aceticlofenac, etc., may increase the risk of gastrointestinal bleeding and discomfort; in addition, naproxen is the treatment of rheumatoid arthritis, gout, etc., which has the effect of inhibiting platelet aggregation, and clopidogrel at the same time, may also increase the risk of gastrointestinal bleeding. Additional attention should be paid to the fact that grapefruit juice decreases the serum concentration of the active metabolite of clopidogrel, so the intake of grapefruit juice should be avoided while taking clopidogrel tablets.