Quadruple therapy is the current recommended protocol for treating H. pylori, and patients are required to take the medication as prescribed. When patients are clinically diagnosed with H. pylori infection, quadruple therapy is often chosen to treat the disease in order to promote the recovery of health. Quadruple therapy is mainly proton pump inhibitors + bismuth + two antibiotics. Commonly used proton pump inhibitors include omeprazole, lansoprazole, pantoprazole and so on. For bismuth, colloidal bismuth citrate is often used clinically. Antibiotic composition scheme has amoxicillin + clarithromycin, amoxicillin + furazolidone, tetracycline + metronidazole, etc.. If the patient is allergic to a certain antibiotic, other antibiotics can be used instead of the treatment as prescribed by the doctor to prevent the occurrence of allergic reactions. It is recommended that those who are clearly infected with Helicobacter pylori should follow the doctor’s instructions to use medication, and should not use medication indiscriminately on their own. During the medication period, patients need to consult the doctor regularly for review, so as to adjust the medication program according to the changes in the condition, and also pay attention to the reasonableness of the diet and hygiene, and avoid drinking raw water or ingesting spoiled food.