Closed-cell pimples are usually found on areas of the face that produce high levels of oil and can produce a white, greasy substance when squeezed. Closed-cell pimples are a clinical manifestation of mild acne, and may recur and remain unresolved if the triggers of acne are not removed. General treatment, medication, and physical therapy are often used to improve the condition. 1. General treatment: Patients are advised to choose mild cleansing products, avoid squeezing and scratching of acne, avoid mental stress and anxiety, and keep daily bowel movement. 2. Medication: patients can use adapalene gel or benzoyl peroxide gel under doctor’s instruction; patients who have the need for quick results can take oral retinoids as prescribed by the doctor. 3. Physical therapy: patients can also be treated by chemical peeling method or acne squeezer. For patients with closed mouth acne, it is recommended to go to a regular hospital in time, under the guidance of a professional doctor for standardized treatment.