Zhi Bai Di Huang Wan is a kind of Chinese patent medicine for treating yin deficiency and fire exuberance (deficiency of yin essence in the body and hyperactivity of deficiency fire) and relieving kidney deficiency. Long-term use of this medicine may cause symptoms such as damage to qi and blood, increase of yin deficiency, and deficiency of spleen and stomach (spleen and stomach are weak and cold). Damage to qi and blood: this drug has the effect of lowering the fire, long-term use may appear chest tightness and shortness of breath, limb weakness, eye fatigue and other symptoms, patients with qi deficiency can not take this drug. Increasing Yin deficiency: This drug has the effect of nourishing Yin and clearing heat (nourishing Yin essence and removing heat and evil). Taking it for a long time may also damage the body and increase Yin deficiency, resulting in symptoms such as fear of cold and loose stools. Weakness of spleen and stomach: This drug contains Poria and Zedoaria, etc. Taking it for a long period of time will lead to weakness of spleen and stomach, and symptoms such as abdominal pain, diarrhea, nausea and vomiting will occur, so it is not suitable for patients with weak spleen and stomach. Zhi Bai Di Huang Wan is one of the commonly used drugs to treat kidney deficiency, patients should follow the doctor’s instructions to take, if you feel uncomfortable, it is recommended to consult a doctor in a timely manner, so as not to cause damage to the body.