Nowadays, cranial trauma and craniosynostosis are very common and have a great impact on health, requiring craniotomy if necessary. In the case of craniotomy, cranial defects are often left behind because they are done through cranial openings. Cranial defects should not be taken lightly, because the skull has a critical protective role for brain tissue, and once they occur, they can have many effects. First of all, from the aesthetic point of view, skull defect is bound to affect the appearance of a piece of appearance, and the patient may become inferior and depressed; secondly, once the skull defect occurs after the bump, the brain tissue will be injured, and the intracranial pressure intracranial environment will be changed, which will lead to a series of skull defect syndrome. It can be seen that when the problem of cranial defect exists, we should pay attention to it, and it is crucial to go to the hospital for cranial bone repair surgery in time. How to repair the skull after craniotomy? It is generally recommended to perform cranial bone repair surgery about 2-3 months after surgery, which is more conducive to recovery. At the same time, the skull repair surgery should also pay attention to the choice of materials, good materials have better post-operative effect. At present, many local hospitals commonly use titanium mesh material, but because it is a metal material and adopts the overlay repair method, not only infection and rejection may occur after surgery, but also irritation to the scalp, and there is a possibility of material exposure after a long time. Our team has adopted a safer and more advanced PEEK material that allows for a one-time replacement and an initial repair. We recommend that patients with initial repairs use PEEK if possible, as it has better properties than titanium and is almost equivalent to autologous cranial bone, making it an ideal repair material. Furthermore, our team has been continuously exploring and researching, constantly upgrading the technology and optimizing the design of the material, applying the concept of aesthetic plastic surgery to the procedure, and carrying out comprehensive PEEK cranioplasty, which is highly praised by patients for its ability to repair the skull while being aesthetically pleasing.