The disease is a very complex disease that involves multiple systems and has an unknown pathogenesis, and most patients first show recurring mouth ulcers. The treatment of oral ulcers caused by leukoplakia can generally choose drug therapy, in more serious cases, surgery is required. 1, drug therapy: leukoplakia most often causes oral ulcers, treatment of oral ulcers can be localized using gentian violet, watermelon cream, etc. coated ulcer surface, can also be injected in the lesion site corticosteroids or the use of hormonal sprays, combined with tacrolimus use to reduce pain. Oral tetracycline solution or the use of colchicine to rinse the wound can also be used to promote healing of the ulcer. For patients with more severe pain, it is recommended to use some local anesthetics to relieve the pain under medical supervision. In addition to this, clinical studies have shown that thalidomide is more effective than other drugs for the treatment of leukoplakia, but thalidomide has serious teratogenic effects, so in the process of using thalidomide for leukoplakia, doctors and patients need to strictly follow the guidelines for the use of thalidomide, follow up regularly and adjust the dosage according to the condition in time to avoid serious side effects of the drug; 2. Surgical treatment: ulcers that are huge and Affecting daily work and life, surgery is needed to completely remove the diseased tissues in the oral cavity, and all the areas involved in the lesions should be completely removed, such as muscles, fat, mucous membranes, lymphatic tracts, etc. Surgical treatment can both appropriately reduce the patient’s pain and achieve the purpose of alleviating disease progression. In addition, it is also necessary to do a good oral hygiene in daily life, try to eat lightly, avoid staying up late and ensure sufficient sleep to avoid further development of the disease. However, the lesions of leukoaraiosis involve several systems, and the treatment effect is not good only for oral ulcers, which can easily lead to recurrence of the disease and migration of the disease process. Therefore, in addition to the treatment of oral ulcers, it is necessary to adhere to the systematic and regular treatment of leukoaraiosis according to the guidance of the doctor in order to slow down the development of the disease.