In clinical practice, we often hear the term “degenerative”. What is a degenerative lesion? Where does it occur? As we age, various parts of the human body will experience aging and degeneration of varying severity after middle age. In the clinic, this and that physical discomfort, that is, affect the work and study. It brings a lot of inconvenience and trouble to life. Degenerative changes generally refer to degenerative lesions of the bone and joint. Age is the main risk factor for degeneration, which is caused by the wear and tear of cartilage due to imbalance of mechanical stress distribution or excessive loading over a long period of time. Generally, after the age of 35, the intervertebral discs between the vertebral bodies are subject to degeneration. Elasticity and toughness are reduced, resulting in disruption of the physiological balance of the joint capsule, and the body has to adjust itself to these changes in the internal environment to establish a new balance, while new bones grow at the edge of the vertebral body, which is commonly referred to as osteophytes, or bone spurs. In middle-aged and elderly people, some secondary osteophytes occur during the growth process, which is a self-compensatory response of the body and a protective mechanism of the human body, so it is said that some people suffer from osteophytes without any clinical discomfort. However, as we age, the bone spur grows, and once we fail to regulate ourselves, changes in the internal environment and metabolic dysfunction occur. The soft tissue around the bone spur becomes congested, edematous, inflamed, and adherent. This is called degenerative bone and joint disease, and must be taken seriously. Lesions occurring in different parts of the body can cause different symptoms. 1, cervical degenerative lesions cervical collar with a stiff feeling, restricted movement, neck activities with a popping sound, pain often radiates to the shoulders and upper limbs, numbness and electric shock-like sensation in the hands and fingers, which can be aggravated by neck activities to a certain angle. Different lesions involve different parts of the body and present different symptoms. In severe cases, the cervical medulla can be compressed, leading to paralysis. Certain types of cervical spine can also cause cervical vertigo, cervical hypertension, cardiovascular disease, gastritis, angina pectoris, dysphagia, etc. 2.Degenerative lesions of the lumbar spine are most common in lumbar three and four. Clinically, the lumbar spine and the soft tissues of the lumbar region often experience soreness, swelling, stiffness and fatigue, and even restricted bending. If the adjacent nerve roots are compressed, it may cause corresponding symptoms, such as local pain, stiffness, posterior root neuralgia and numbness. If the sciatic nerve is compressed, it can cause sciatic neuritis, with radiating numbness, burning pain, throbbing pain, string pain, and radiation to the entire lower limb, and intermittent claudication when it leads to spinal stenosis. 3. Knee degenerative disease The knee pain is not serious if the disease starts slowly, sustainability hidden pain, the pain increases when the temperature decreases, related to climate change, the morning after starting to move, walking for a long time, strenuous exercise or sedentary starting to walk when the knee pain stiffness, a little activity after the improvement, up and down the stairs is difficult, down the stairs when the knee is weak, easy to fall. Pain and stiffness when squatting, in severe cases, joint pain and swelling, limp, joint function is limited, most obvious in squatting, stretching and flexion activities have a popping sound, some patients can see joint effusion, local swelling, pressure pain phenomenon, combined with rheumatism, joint redness, swelling, deformity. There are obvious clinical symptoms, the need for treatment, clinical treatment methods include Chinese and Western medicine, physical therapy, surgery and so on. Western medicine treatment is not yet effective in Western medicine, often using symptomatic treatment, such as pain can take some antipyretic and analgesic drugs; numbness can use B vitamins; joint swelling with fluid can be given to local extraction of fluid or local closure and other therapies. Chondroprotective agents such as glucosamine sulfate can promote the synthesis of cartilage, inhibit the dissolution of articular cartilage, and also have anti-inflammatory effects. They can be used as basic treatment for a long time. When conservative treatment is not effective and the disease is severe and seriously affects the patient’s life, surgery can be considered. We will not go into details here.