Masturbation generally does not cause prostate enlargement, the cause of prostate enlargement has not been clearly defined, and is considered to be related to the role of growth factor neurotransmitters. The cause of prostate hyperplasia is not yet clear, some studies have shown that it may be related to the role of growth factor neurotransmitters in prostate tissue, the role of sex hormones, cell proliferation and apoptosis, and prostate mesenchymal gland epithelial interactions and other factors. Moderate masturbation usually does not have an effect on the organism, but too much masturbation may make the prostate in a long-term state of congestion, easy to cause prostate edema, will affect the prostate excretion function, may induce prostatitis, but will not cause prostate hyperplasia. It is recommended that patients should control the number of times of masturbation and avoid frequent masturbation, because frequent masturbation may lead to erectile dysfunction or mental depression. For patients with prostate enlargement, they need to seek timely medical treatment, and the doctor will take appropriate measures to treat the patient’s condition.