The best time to repair the skull after craniotomy, the human body is a very sophisticated life system, each organization plays an important role in their own, each link is essential. For example, the skull is a very important group of bone tissue in the human body, responsible for the protection of intracranial soft tissue, maintaining a stable intracranial environment and other important roles. The skull is very hard, and under normal circumstances can withstand most of the general impact of the outside world. However, in reality, we are always faced with many unknown risks, and the skull is not indestructible under the action of some irresistible factors. For example, some traffic accidents, falling objects, production safety accidents, surgical procedures, etc., may cause skull defects. Once the skull is damaged, it should be repaired in time, otherwise it may cause damage to the human body, sometimes very serious damage, or even fatal damage. So when is the best time for cranial repair? Generally speaking, if it is a clean open wound without intracranial hypertension, cranial bone repair surgery can be performed immediately; while if it is due to intracranial hypertension and decompression surgery with debridement flap resulting in cranial bone defects, it will take about three months for the intracranial pressure to stabilize, and then repair it again. So the timing of cranial bone repair is very important, in addition to the choice of cranial bone repair material is also very important. Some patients use titanium mesh material for skull repair in some hospitals, but it often fails to achieve a good repair effect, or there are some uncomfortable reactions after the operation. In fact, there is a more ideal cranial bone repair material, called polyether ether ketone, also known as PEEK material, performance is very excellent. The use of this advanced cranial bone repair materials, can be achieved very good repair results. PEEK material is a special polymer material, due to the material’s good biocompatibility, can be complex shaping, excellent mechanical properties, good protective properties, postoperative comfort, gradually become the latest trend of cranial bone repair materials.