The side effects of retinoic acid cream are local irritation of the skin, erythema, flaking and burning sensation in the first few weeks of treatment, which may make the lesions more visible, but this indicates that the drug is working, not that the condition is worsening. If the reaction persists and worsens, the drug should be temporarily discontinued or reduced, and is contraindicated in women during the first trimester of pregnancy. Vitamin A cream can induce epidermal hyperplasia, regulate epithelial keratinization of follicular sebaceous glands, exfoliate keratin plugs, and affect melanogenesis in melanocytes, making it suitable for the treatment of acne, chronic sun damage, photoaging skin, psoriasis, lichen planus, palmoplantar keratosis, chloasma, etc. However, during the course of use, due to the fact that the drug is not suitable for the treatment of acne, it is not suitable for the treatment of acne. However, due to side effects in the process of medication, it is recommended to use a small amount on the lesions and try not to apply it on the normal skin to avoid irritation reactions.