Neuron disease usually refers to motor neuron disease (MND), the clinical manifestations of which are muscle weakness and atrophy, medullary paralysis, and pyramidal fasciculus sign, mostly middle-aged onset, usually due to genetics, infection and immune function abnormalities, heavy metal poisoning, nutritional disorders and other factors: 1, genetics: some family genetic history can be found in the obvious tendency to gather MND patients, chromosomal dominant inheritance, the most common causative The most common causative gene is the copper (zinc) superoxide dismutase gene; 2, infection and abnormal immune function: the onset of MND is associated with prions, HIV and other viral infections, and chronic viral infections can lead to MND attacks; 3, heavy metal poisoning: the onset of MND is associated with heavy metal poisoning or elemental deficiency, such as aluminum, and retrograde axonal flow of aluminum can cause anterior horn cell poisoning, leading to MND; 4, nutritional disorders: such as After gastrectomy in some patients, nutritional absorption is impaired, leading to vitamin B1 deficiency, which can cause MND; 5, other: patients with reduced levels of inhibitory neurotransmitters and elevated norepinephrine can lead to MND attacks. In addition, bad living environment and stimulation of chemical substances can also induce MND.