The duration of life with B-type natriuretic peptide 1000 pg/ml depends on the patient’s specific situation and cannot be generalized. B-type natriuretic peptide, BNP, is a peptide composed of amino acids secreted by ventricular myocytes and is used to diagnose acute heart failure and chronic heart failure, as well as to grade the severity of heart failure and to assess the prognosis. If BNP is less than 100 pg/ml, chronic heart failure is unlikely. If BNP is greater than 400 pg/ml, the possibility of chronic heart failure is considered. Thus a B-type natriuretic peptide of 1000 pg/ml can be diagnosed as heart failure. Heart failure is a chronic disease, and if the patient’s primary disease causing heart failure is mild, the disease may be reversible; and some of the more severe heart failures often do not affect the patient’s life expectancy after a late heart transplant. If the patient’s primary disease is poorly controlled or not treated aggressively, allowing the heart failure to progress further; or if the patient with severe heart failure does not take medication in a timely manner, both can be life-threatening at any time. In conclusion, the elevated level of BNP is positively correlated with the severity of heart failure; the more severe the heart failure, the more significant the elevated BNP level, and the worse the prognosis will be. Patients with B-type natriuretic peptide 1000 pg/ml are recommended to be seen in cardiovascular medicine in a timely manner and to cooperate with active treatment.