If the diabetic patient’s condition is in remission, the blood sugar control is getting smoother and smoother, and the blood sugar can reach the standard when no medication is used, it is possible to discontinue Metformin under the guidance of the doctor. Metformin is used in the treatment of diabetes mellitus, the adverse effects are mainly gastrointestinal adverse reactions, such as anorexia, bloating, nausea, vomiting, abdominal pain, diarrhea and so on. Metformin is contraindicated in patients with diabetic ketoacidosis, heart failure, severe infections and trauma, hepatic and renal insufficiency, alcoholism, and vitamin B12 and folate deficiency. Patients with obesity-related type 2 diabetes mellitus who are on medication along with weight control, active diet and exercise therapy, and whose blood glucose can be controlled steadily without the use of medication, may discontinue metformin after evaluation by a physician, but not on their own. Both the use and discontinuation of metformin should be under the supervision of a doctor.