How much total bile acid exceeds is dangerous, and it should be judged according to the type of disease. Total bile acid >10μmol/L is considered abnormal, and if physiological causes are ruled out, attention should be paid to improve the relevant examinations and early treatment. Serum bile acids are obviously increased in hepatobiliary diseases, which is a very sensitive liver function test. 1. 100% of total bile acids are increased in acute hepatitis, acute intrahepatic cholestasis, primary hepatocellular carcinoma, cirrhosis, primary biliary cirrhosis and extrahepatic cholestatic jaundice. 2. Chronic active hepatitis should be considered more often when total bile acid >20 μmol/L. 3. Cirrhosis is very likely when total bile acid >30μmol/L. 4. The total bile acids in chronic prolonged hepatitis were (7.7±4.6) μmol/L and (23.6±12.5) μmol/L in fasting and 2 hours after meal, respectively; and (78.7±38.9) μmol/L and (111.3±45.1) μmol/L in chronic active hepatitis, respectively. Therefore, the values of total bile acids are different for different types of diseases. The specific situation should be comprehensively judged under the guidance of a doctor.