Although the mainstream orthodontic techniques currently used at home and abroad generally follow the principle of gentle and light force. Usually, under the action of appropriate orthodontic force, the orthodontic teeth do not experience obvious or unbearable pain, but they are not senseless. Most patients may experience mild pain at the beginning of orthodontic treatment or after the archwire force is applied, or it may manifest itself as a feeling of soreness and swelling, which prevents them from biting on hard foods, but it can usually be relieved and adapted in a few days. There is a large individual variability in whether or not significant pain occurs after the force is applied to the orthodontic teeth. Under the same orthodontic force, pediatric patients generally have a better tolerance of pain response than adult patients. In most patients, the pain is more pronounced in the first 3 to 4 weeks of treatment and then gradually disappears. Inappropriately excessive orthodontic forces may induce periodontal tissue damage, resulting in orthodontic toothache. In addition, in the process of tooth movement, due to the new occlusal balance contact relationship has not yet been established, occlusal interference between the upper and lower teeth may occur, resulting in traumatic contact between the tips of the teeth, and also traumatic tooth pain. If this occurs, occlusal interference should be eliminated and the pain will subside. In general, it is very rare that orthodontic pain requires painkillers.