Possible side effects of Coptisine Water Wet Compress are skin allergic reactions. The 2015 edition of the Chinese Pharmacopoeia points out that berberine hydrochloride, the active ingredient of Huanglian, has a bactericidal and anti-inflammatory effect, so the clinic will use the wet compress of Huanglianin water to treat eczema. However, while Huanglianin water kills bacteria, it may also produce skin toxicity, and some patients may have skin allergic reactions, including itching, pain, redness, swelling, scaling, erythema, and pimples of the skin. When skin allergic reaction occurs, patients should immediately stop wet compresses, and wash the face with water to remove residual drug ingredients. If itching occurs, avoid scratching; if scaling occurs, urea ointment or baicalin ointment can be used to moisturize and emollient; if erythema papules and other symptoms of drug-sensitive urticaria occur, it is recommended to seek medical attention as soon as possible. It is worth noting that, when treating the disease, the yellow dock can be applied wet, but whether to use the wet treatment method, and how to proportion the yellow dock, it is still recommended that the patient to the regular hospital after consultation, follow the doctor’s instructions, do not blindly use the drug.