The signs of endometrial cancer cannot be simply defined as six. Common early symptoms include irregular vaginal bleeding, vaginal discharge, more obvious abdominal pain, etc. In the middle and late stages, if the tumor invades the cervix and parametrium or even the vagina, thickening, nodules or vaginal lesions may appear in the parametrium: 1. Vaginal bleeding: About 90% of endometrial cancer patients have irregular vaginal bleeding, which usually occurs after menopause or during perimenopause. For patients with irregular vaginal bleeding during perimenopause, general physical examination and gynecological examination, especially ultrasound examination, are needed to exclude endometrial cancer. 2. Vaginal discharge: In early stage, abnormal discharge of blood or pulpy discharge from the vagina may occur, and if the discharge is pus and blood-like with bad odor, it indicates local infection or necrosis. 3. This may lead to intrauterine fluid accumulation, which may lead to abdominal distension and pain or cramping pain. If the tumor compresses the peripheral nerves in the process of growth, it will cause pain in the lower abdomen and waist. In addition, when the tumor develops to the middle and late stage, it will be accompanied by fever, emaciation, anemia, or complications such as infertility. Currently, according to big data, women with Lynch syndrome are the high-risk group for endometrial cancer, and the incidence rate can be as high as 60%. Therefore, patients with Lynch syndrome are recommended to have regular endometrial biopsies.