Nerve entrapment can lead to numbness in both feet, especially in pyriformis syndrome. When the patient’s sciatic nerve is compressed in the buttocks, inducing pyriformis syndrome, it may manifest as numbness in both feet, buttock pain, painful claudication, abnormal skin sensation, and muscle atrophy of the lower limbs. Other diseases lead to lower limb nerve entrapment syndrome, can also appear numbness of feet, such as peroneal nerve, tibial nerve entrapment and so on. There are many causes of numbness of the feet, such as maintaining poor posture for a long time, lumbar intervertebral disc herniation, diabetes mellitus, varicose veins of the lower limbs, etc., and attention should be paid to identify. For nerve compression caused by numbness of the legs, can follow the doctor’s instructions with methylcobalamin, vitamin B1, etc. to relieve the symptoms, but also for medical treatment of heat therapy, electrotherapy and other physical therapy, serious cases can also be surgical treatment. It is recommended that people with numbness in legs caused by nerve entrapment should actively cooperate with doctors, and should not use medicines or prescriptions indiscriminately on their own.