Clinically, 15mm gallbladder stones are a serious disease that should be given enough attention and vigilance. As gallstones with a diameter of 15mm do not cause clinical symptoms, the long-term presence of gallstones in the gallbladder may repeatedly irritate the mucosa of the patient’s gallbladder, causing the possibility of gallbladder cancer in the patient, and therefore the patient is advised to undergo surgery as early as possible. Of course, if the gallstones are 15mm, it will cause clinical symptoms such as pain, nausea, vomiting, abdominal distension, fever and so on in the patient’s right upper abdomen, and the patient should be operated in time. And the perioperative period should strengthen the anti-infection treatment, maintain the water-electrolyte balance, and give patients active nutritional support. The postoperative period should strengthen the dressing change treatment of the incision, which is favorable to the patient’s health recovery. Patients should go to the hospital for examination in time and be treated under the guidance of doctors.