Alcohol is metabolized in the body by the liver, and the metabolism time varies individually, and is mostly completed in about 24-48 hours. The metabolism of alcohol in the body requires two enzymes in the liver, namely ethanol dehydrogenase and acetaldehyde dehydrogenase. The amount of ethanol dehydrogenase in the human body does not vary much, but there are more people who lack acetaldehyde dehydrogenase, resulting in individual differences in the metabolism rate of alcohol in the body. Usually, a small amount of alcohol can be metabolized in 24 hours; those who drink more alcohol or lack acetaldehyde dehydrogenase may need 48 hours to metabolize it completely; and those who reach the state of intoxication will take longer to metabolize. At the same time, the physical condition, gender and age of the drinker will also affect the metabolism time of alcohol in the body. Therefore, it is recommended to drink more water, fruit juices and sugar-sweetened beverages after drinking alcohol, and to exercise moderately to help accelerate alcohol excretion and reduce post-drinking discomfort.