Liver failure is a syndrome in which liver synthesis, detoxification, excretion and biotransformation functions are severely impaired or uncompensated due to various reasons, and coagulation dysfunction, jaundice, cirrhotic ascites and hepatic encephalopathy are the main clinical manifestations. According to the pathohistological characteristics, liver failure is divided into acute liver failure, subacute liver failure, slow plus acute liver failure and chronic liver failure. According to the severity of clinical manifestations, subacute liver failure and slow plus acute liver failure can be categorized into early, intermediate and advanced stages. The treatment of liver failure includes three aspects: 1, internal medicine comprehensive treatment, including appropriate rest, reasonable nutrition 2, symptomatic treatment: those with bleeding tendency immediately supplement coagulation factors to prevent bleeding of important organs, severe ascites can be diuretic, puncture and release of ascites, supplemental albumin, ascites autologous re-infusion and so on. 3.Treatment for primary disease: Early detection of liver failure can be achieved through the treatment of the primary disease to obtain satisfactory therapeutic effect, late liver failure causes little therapeutic value to symptomatic supportive treatment. 4, for sudden liver failure, hepatic encephalopathy and other serious complications can be eliminated through dialysis and other means of toxic substances on the body of other important organs of the damage, and later to the symptomatic supportive treatment. Liver failure is a serious internal disease, there is no complete cure for it, so regular physical examination to prevent liver injury from developing into liver failure as a secondary prevention means is the best prevention and treatment for liver failure.