There are many causes of constipation, including personal factors, environmental factors, colorectal and anal diseases (inflammatory bowel disease, hemorrhoids, anal fissure), extra-intestinal diseases (cerebral infarction, hypothyroidism), functional constipation and so on. When taking Prucalopride or still have difficulty in bowel movement, it is recommended to improve the symptoms by adjusting lifestyle habits or changing medication under the guidance of a doctor and in conjunction with one’s own situation. Prucalopride can promote gastrointestinal peristalsis to promote defecation. If the drug is ineffective, you can improve the symptoms of constipation by eating a light diet, eating more vegetables and fruits, eating foods rich in dietary fiber, avoiding spicy and stimulating foods, reducing oil and salt, quitting smoking and drinking, drinking more water, exercising reasonably, and keeping a happy mood. Non-pharmacological treatment is ineffective, you can change the drugs under the advice of the doctor, you can choose the drugs include lactulose, keserol, etc. Drugs do not exist absolute effective, need to strictly follow the doctor’s instructions to use, the emergence of adverse reactions to timely consultation, drug allergy is prohibited.