Cisplatin and carboplatin are both platinum-based antitumor drugs, but these two chemotherapeutic drugs are different. The differences between cisplatin and carboplatin are: First, the antitumor spectrum of the two drugs is different, there is no cross-resistance between the two drugs, when the clinical application of cisplatin is ineffective or cannot tolerate the toxic side effects of cisplatin, consider switching to carboplatin for antitumor treatment. The main adverse effect of cisplatin is nephrotoxicity. When cisplatin is used in large quantities in clinical practice, attention should be paid to hydration to reduce the occurrence of nephrotoxicity, and cisplatin is also a highly emetogenic chemotherapy drug. The main adverse effect of carboplatin is myelosuppression, and many patients will have severe platelet drop after applying carboplatin. Third, the calculation of the dosage of the two drugs is also different. Clinically, the dosage of cisplatin is calculated according to the body surface area of the patient, while the dosage of carboplatin is calculated according to the AUG.