A booster shot of the New Crown vaccine can be given during menstruation if there is no serious physical discomfort. If there is serious physical discomfort, such as immunocompromised, severe anemia, or allergy to the vaccine, it is not advisable. Currently, most of the new crown vaccines are inactivated virus strains, which will cause a slight immune response and antibody production in the body after injection. Rapid hormonal changes during menstruation can reduce immunity, but usually do not affect the body’s immune response to inactivated strains. If menstruation is combined with serious physical abnormalities such as severe cold, asthma, active infectious diseases, hypoproteinemia, etc., booster injection of New Crown Vaccine is generally not recommended to avoid aggravating the immunocompromise, and can be repeated within a specified period of time after slight recovery from the disease. It is recommended that women who need a booster shot during their menstrual period should go to the CDC for counseling and get the shot according to their own situation, so as not to affect the effectiveness of the shot.