Does the absence of “three more and one less” necessarily mean that the person is not diabetic? To answer this question, we need to do a comprehensive analysis. Although the incidence of diabetes is increasing, there are not many diabetic patients who usually visit the diabetes specialist clinics in major hospitals with “three more and one less” as their main complaint. It is more common that diabetes is “mixed” with other diseases and is detected by occasional simultaneous blood glucose testing. What are the factors at play? The reason is that in the early stages of diabetes, when the elevation of blood glucose is not so obvious, there may be no discomfort or only one or two of the symptoms may appear, and they are often atypical and may come and go, intermittently, often not enough to alert the patient to pay attention, or even to be unaware of them. Secondly, the sensitivity of each person to perceive changes in the internal and external environment varies, and some people may react very strongly to the same level of change and the same intensity of stimulation, while others may not react or react slightly. This is also the case with the individual’s perception of changes in blood glucose levels. Therefore, people with typical “three more and one less” symptoms should be considered a sign of diabetes and should seek medical confirmation. Those who do not have typical symptoms should also raise their awareness of self-care and be examined at an early stage to rule out diabetes. In conclusion, while the “three more and one less” symptoms are important for detecting diabetes, they are not sensitive to most patients and therefore are not an early warning sign of diabetes. Clinically, they should not be dismissed or confirmed on the basis of this alone, as this will delay the early diagnosis and treatment of diabetes. In addition, the symptoms of “three more and one less” can also be seen in other diseases, such as enuresis, psychogenic thirst, and sometimes hyperthyroidism, and need to be differentiated on a case-by-case basis. Therefore, “three more and one less” is not unique to diabetes, and the specificity is not 100%. So, what can we do to prevent diabetes and keep it under control in the bud? The most advisable way is to have regular medical checkups and blood glucose testing. Regular annual health checkups are a proven method and should be carried out in the general population. Secondly, and most importantly, it is important to promote a healthy lifestyle throughout the community, to eliminate bad habits, and to start from the root causes that may produce diabetes. As long as we do so, although diabetes can not and will not disappear from now on, but will greatly reduce the incidence, is the onset of the disease, because the timely detection and treatment, can avoid or delay the disease brought about by disability and quality of life decline, to reduce the burden of individuals, families and society has a positive significance.