Joint pain when taking Letrozole tablets for breast cancer may be caused by osteoporosis; it can be treated with diphosphonates under the guidance of doctor, common ones are etidronate tablets and clodronate disodium tablets, and calcium supplementation can also be carried out. It may also be caused by diseases originating in the joints, at which time the primary disease needs to be treated. Osteoporosis caused by Letrozole tablets can be treated by taking etidronate sodium tablets and clodronate disodium tablets. Bisphosphonates are a new class of drugs used in various types of bone disorders and calcium metabolism diseases for the treatment of osteoporosis and other diseases. It is contraindicated for those who are allergic to the above drug and those with severe kidney damage. Symptoms such as diarrhea, vomiting and headache may occur after taking the said drug, in which case it should be stopped immediately. Patients can also undergo calcium supplementation therapy under doctor’s guidance, such as applying calcium carbonate tablets. In addition, diseases originating in the joints may also lead to joint pain, such as arthritis, gout, etc.; at this time, we should consult the doctor in time and follow the doctor’s instructions for treatment. For example, patients with rheumatoid arthritis can be treated with indomethacin, diclofenac sodium and other drugs; gout can be treated with colchicine, prednisone and other drugs. The specific application of what drugs should be determined by the doctor according to the patient’s specific situation. When breast cancer patients are taking Letrozole tablets for joint pain, they should go to the hospital in time, and actively cooperate with the doctor’s treatment after clarifying the cause of the disease.