Calcium-regulated neurophosphatase inhibitors Include tacrolimus ointment and pimecrolimus cream. Pimecrolimus is a local immunomodulator that selectively inhibits the production and release of inflammatory cytokines. Pimecrolimus inhibits calcium-dependent phospholipase activity, which inhibits T-cell function as well as the production of various cytokines, and also promotes the growth of pigment cells and pigment-forming cells by affecting keratin-forming cells, which promotes local skin pigment re-formation and achieves the purpose of vitiligo treatment. It was found that: tacrolimus ointment combined with excimer light irradiation or topical application of compound kalizarin tincture can promote the fading of white spots; pimecrolimus ointment combined with excimer light irradiation can reduce the number of light exposure. The treatment time is 3-6 months, and the areas with the best re-coloring effect are the face and neck. Mucous membrane areas and genital areas can also be used. There are no side effects caused by hormones, especially strong hormones, but care should be taken to increase local infections such as folliculitis. Topical photosensitizers Methicillin application, compound Kalizarin tincture, tincture of bone marrow, compound Angelica dahurica tincture and tincture of white removal belong to photosensitizing drugs Instrument use, improve skin hypersensitivity, reduce the time of illumination, can be used half an hour before illumination. Compound Kalizarin Tincture: It has the efficacy of warming the skin and dispersing cold, dispelling wind and drying dampness, soothing the meridians, activating blood circulation and removing abnormal mucus, increasing the photosensitivity of the skin, activating tyrosinase activity and promoting the synthesis of melanin in the skin. A few patients may experience redness, swelling, itching and other reactions at the drug site, and some local blisters may appear. If redness and blisters appear during photosensitizer treatment, you can suspend the use of photosensitizing drugs, apply cold and wet compresses to the red and swollen areas, and do not pick through the blisters to avoid infection. Hormones including Halometasone, Neosynthesis, Eloson, Halometasone (Aunen), Denide cream, etc., with anti-inflammatory, immunosuppressive, anti-nuclear division, etc., local application can reduce the immune inflammatory reaction of vitiligo and reduce the immune damage of autoantibodies to melanocytes. In addition, corticosteroid topical application can also cause local skin melanin deposition, which also plays a role in treatment. Topical hormones are easy to use, have good transdermal properties, and systemic adverse effects are rare, but avoid large areas and prolonged use. Vitamin D3 derivatives Carbofurantrinol (Darex) and tacalcitol are mainly psoriasis treatment drugs. Topical carbofurantrinol and tacalcitol can be used to treat vitiligo and applied topically twice a day. It can be combined with narrow spectrum UVB, 308nm excimer laser, PUVA and so on. It can also be combined with topical hormones and calcium-regulated neurophosphatase inhibitors with better efficacy than alone. Adverse reactions of tacalcitol or carbotriol alone or in combination for vitiligo are mild, common ones are itching, erythema, dryness, rare ones are irritation, desquamation, burning sensation, maceration, hair growth, capillary dilation, etc. All adverse reactions are temporary, in the tolerable range and do not affect the continuation of treatment. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The vitiligo cover-up therapy is only applicable to the exposed parts and the small area of the white spot affected by the long treatment, but should not be used for a long time, so as not to affect the vitiligo treatment effect. The actual skin is not recommended to use the covering agent when the skin is injured; to thoroughly clean the place where you want to apply, the degree of cleanliness will directly affect the time and effect of the covering, avoid rubbing the skin when cleaning; according to the individual normal skin color, different parts of the disease, and the absorption ability of the product in each part, the number of times of application and the thickness of the coating is also different, the normal skin is lighter, the parts with good absorption only need to be applied once. The darker and poorly absorbed parts of the skin need only one application, while the darker and poorly absorbed parts need several more applications. The tincture of nitrogen mustard hydrochloride, the main component of which is nitrogen mustard hydrochloride, is rubbed externally on the white spots and forms an ethylene imine group after penetration into the skin, which can act with the sulfhydryl group to activate and accelerate melanin production by melanocytes. This drug is fast acting, but the regenerated pigment is easy to disappear after stopping the drug. At present, this method is still one of the common methods for the treatment of vitiligo. However, the tincture of azelaic acid tincture is susceptible to sensitization, and long-term use of the drug has a tendency to cause cancer. The use of nitrogen mustard hydrochloride irritating drugs developmental period caution, can be small area test, if not allergic can continue to use, if allergy and other symptoms should be stopped immediately to avoid leading to isomorphic reaction. This treatment has the advantages of being simple, convenient, effective and inexpensive. The disadvantage is that the pain is obvious.