Clinically, intermuscular vein thrombosis in the calf is not likely to heal on its own. Therefore, once a patient is found to have intermuscular vein thrombosis in the calf, the patient must be given anticoagulation therapy. In the clinic, the commonly used anticoagulant drugs include low molecular heparin sodium, enoxaparin sodium, warfarin, rivaroxaban and dabigatran, which must be applied only under the guidance of professional doctors. Moreover, it depends on the patient’s condition. It should be noted that the coagulation function of the patient must be monitored regularly during the treatment of calf intermuscular vein thrombosis to prevent bleeding from the mouth, nasal cavity or gastrointestinal tract. It is also important to note that anticoagulation therapy for intermuscular vein thrombosis of the calf is usually carried out for 3 months. within 3 months, the patient should visit the hospital every month to review the changes of intermuscular vein thrombosis of the calf, so that the monitoring of the intermuscular vein of the calf can be facilitated.